Ontology highlight
ABSTRACT:
SUBMITTER: Botusan IR
PROVIDER: S-EPMC2614777 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Botusan Ileana Ruxandra IR Sunkari Vivekananda Gupta VG Savu Octavian O Catrina Anca Irinel AI Grünler Jacob J Lindberg Stina S Pereira Teresa T Ylä-Herttuala Seppo S Poellinger Lorenz L Brismar Kerstin K Catrina Sergiu-Bogdan SB
Proceedings of the National Academy of Sciences of the United States of America 20081204 49
Relative hypoxia is essential in wound healing since it normally plays a pivotal role in regulation of all the critical processes involved in tissue repair. Hypoxia-inducible factor (HIF) 1alpha is the critical transcription factor that regulates adaptive responses to hypoxia. HIF-1alpha stability and function is regulated by oxygen-dependent soluble hydroxylases targeting critical proline and asparaginyl residues. Here we show that hyperglycemia complexly affects both HIF-1alpha stability and a ...[more]