Ontology highlight
ABSTRACT:
SUBMITTER: Balamotis MA
PROVIDER: S-EPMC2774526 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Balamotis Michael A MA Pennella Mario A MA Stevens Jennitte L JL Wasylyk Bohdan B Belmont Andrew S AS Berk Arnold J AJ
Science signaling 20090505 69
Transcript elongation by polymerase II paused at the Egr1 promoter is activated by mitogen-activated protein kinase phosphorylation of the ternary complex factor (TCF) ELK1 bound at multiple upstream sites and subsequent phospho-ELK1 interaction with mediator through the MED23 subunit. Consequently, Med23 knockout (KO) nearly eliminates Egr1 (early growth response factor 1) transcription in embryonic stem (ES) cells, leaving a paused polymerase at the promoter. Med23 KO did not, however, elimina ...[more]