Serum BLyS levels increase after rituximab as initial therapy in patients with follicular Grade 1 non-Hodgkin lymphoma.
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ABSTRACT:
SUBMITTER: Ansell SM
PROVIDER: S-EPMC2774736 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
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Serum BLyS levels increase after rituximab as initial therapy in patients with follicular Grade 1 non-Hodgkin lymphoma.
Ansell Stephen M SM Novak Anne J AJ Ziesmer Steven S Price-Troska Tammy T LaPlant Betsy B Dillon Stacey R SR Witzig Thomas E TE
American journal of hematology 20090201 2
Serum B-lymphocyte stimulator (BLyS) levels are elevated in a subset of non-Hodgkin lymphoma (NHL) patients, particularly those with a family history of B-cell malignancies or a polymorphism in the BLyS gene. BLyS promotes growth of malignant B-cells and increased serum BLyS levels are associated with a poor clinical outcome. In this study, BLyS levels were measured before and after 4 weekly doses of rituximab in 30 patients with previously untreated follicular Grade 1 NHL. A significant increas ...[more]
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