Duvelisib for CLL/SLL and follicular non-Hodgkin lymphoma.
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ABSTRACT:
SUBMITTER: Patel K
PROVIDER: S-EPMC9635582 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Duvelisib for CLL/SLL and follicular non-Hodgkin lymphoma.
Patel Krish K Danilov Alexey V AV Pagel John M JM
Blood 20191101 19
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and follicular lymphoma (FL) represent indolent malignancies characterized by multiple episodes of relapse. Therapy has centered on agents that largely target the B-cell receptor pathway. Duvelisib is a second-generation oral inhibitor of phosphoinositide-3 kinase, downstream of the B-cell receptor pathway, approved in the United States for relapsed CLL/SLL and FL. Duvelisib represents a highly active agent, and ongoing investigat ...[more]
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