Dataset Information
The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women.
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ABSTRACT: Context
In postmenopausal women, endogenous bioavailable testosterone (T) and estradiol (E2) have been positively associated, and SHBG has been negatively associated, with incident type 2 diabetes (T2DM). Previous studies have not explored possible factors explaining these relationships.Objective
Our objective was to examine the association of endogenous sex hormones with incident T2DM in postmenopausal women and possible explanatory factors.Design, setting, and participants
The Multi-Ethnic Study of Atherosclerosis (MESA) is a prospective study that included 1612 postmenopausal women aged 45-84 yr, followed between the years 2000-2006, who were not taking hormone replacement therapy, had no prevalent cardiovascular disease or diabetes, and had complete ascertainment of sex hormones.Main outcome measures
T2DM was defined based on fasting glucose and/or treatment for diabetes.Results
There were 116 incident cases of diabetes during follow-up. Across higher quartiles of bioavailable T and E2 and lower quartiles of SHBG, we found significantly greater hazards of developing incident T2DM (all P for trend
SUBMITTER: Kalyani RR
PROVIDER: S-EPMC2775652 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women.
The Journal of clinical endocrinology and metabolism 20090929 11
<h4>Context</h4>In postmenopausal women, endogenous bioavailable testosterone (T) and estradiol (E2) have been positively associated, and SHBG has been negatively associated, with incident type 2 diabetes (T2DM). Previous studies have not explored possible factors explaining these relationships.<h4>Objective</h4>Our objective was to examine the association of endogenous sex hormones with incident T2DM in postmenopausal women and possible explanatory factors.<h4>Design, setting, and participants< ...[more]