Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects.

ABSTRACT: Experimental studies in GH-deficient patients and in healthy subjects receiving somatostatin-infusion suggest that GH is an important regulator of substrate metabolism during fasting. These models may not adequately reflect the selective effects of GH, and GH receptor (GHR) blockade offers a new model to define the metabolic role of GH.The aim of this study was to investigate the impact of GHR blockade on substrate metabolism and insulin sensitivity during fasting.We conducted a randomized, placebo-controlled, crossover study in 10 healthy young men.After 36 h of fasting with saline or pegvisomant (GHR blockade), the subjects were studied during a 4-h basal period and 2.5-h hyperinsulinemic euglycemic clamp.We measured whole-body and forearm glucose, lipid, and protein metabolism, peripheral insulin sensitivity, and acyl and desacyl ghrelin.GHR blockade significantly suppressed circulating free fatty acids (1226 +/- 83 vs. 1074 +/- 65 micromol/liter; P = 0.03) and ketone bodies (3080 +/- 271 vs. 2015 +/- 235 micromol/liter; P

SUBMITTER: Moller L 

PROVIDER: S-EPMC2775657 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature