Ontology highlight
ABSTRACT:
SUBMITTER: Viquez NM
PROVIDER: S-EPMC2776049 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Viquez Natasha M NM Füger Petra P Valakh Vera V Daniels Richard W RW Rasse Tobias M TM DiAntonio Aaron A
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090901 37
The synapse is composed of an active zone apposed to a postsynaptic cluster of neurotransmitter receptors. Each Drosophila neuromuscular junction comprises hundreds of such individual release sites apposed to clusters of glutamate receptors. Here, we show that protein phosphatase 2A (PP2A) is required for the development of structurally normal active zones opposite glutamate receptors. When PP2A is inhibited presynaptically, many glutamate receptor clusters are unapposed to Bruchpilot (Brp), an ...[more]