Ontology highlight
ABSTRACT:
SUBMITTER: Kanuka H
PROVIDER: S-EPMC1276714 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Kanuka Hirotaka H Kuranaga Erina E Takemoto Kiwamu K Hiratou Tetsuo T Okano Hideyuki H Miura Masayuki M
The EMBO journal 20051013 21
Caspases are well known for their role in the execution of apoptotic programs, in which they cleave specific target proteins, leading to the elimination of cells, and for their role in cytokine maturation. In this study, we identified a novel substrate, which, through cleavage by caspases, can regulate Drosophila neural precursor development. Shaggy (Sgg)46 protein, an isoform encoded by the sgg gene and essential for the negative regulation of Wingless signaling, is cleaved by the Dark-dependen ...[more]