Ontology highlight
ABSTRACT:
SUBMITTER: Dai J
PROVIDER: S-EPMC2776503 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Dai Jun J Kateneva Anna V AV Higgins Jonathan M G JM
Journal of cell science 20091101 Pt 22
Cohesins and their regulators are vital for normal chromosome cohesion and segregation. A number of cohesion proteins have also been localized to centrosomes and proposed to function there. We show that RNAi-mediated depletion of factors required for cohesion, including haspin, Sgo1 and Scc1, leads to the generation of multiple acentriolar centrosome-like foci and disruption of spindle structure in mitosis. Live-cell imaging reveals that, in haspin-depleted cells, these effects occur only as def ...[more]