Ontology highlight
ABSTRACT:
SUBMITTER: Magescas J
PROVIDER: S-EPMC5431095 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Magescas Jérémy J Sengmanivong Lucie L Viau Amandine A Mayeux Adeline A Dang Tien T Burtin Martine M Nilsson Ulf J UJ Leffler Hakon H Poirier Françoise F Terzi Fabiola F Delacour Delphine D
Scientific reports 20170503 1
Glycosylation is critical for the regulation of several cellular processes. One glycosylation pathway, the unusual O-linked β-N-acetylglucosamine glycosylation (O-GlcNAcylation) has been shown to be required for proper mitosis, likely through a subset of proteins that are O-GlcNAcylated during metaphase. As lectins bind glycosylated proteins, we asked if specific lectins interact with mitotic O-GlcNAcylated proteins during metaphase to ensure correct cell division. Galectin-3, a small soluble le ...[more]