Ontology highlight
ABSTRACT:
SUBMITTER: Lehar SM
PROVIDER: S-EPMC2776671 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Lehar Sophie M SM Dooley James J Farr Andrew G AG Bevan Michael J MJ
Blood 20041014 4
Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Using an in vitro culture system, we show that 2 different classes of Notch ligands, Jagged1 or Delta1, transmit distinct signals to T-cell progenitors. OP9 stromal cells expressing either Jagged1 or Delta1 inhibit the differentiation of DN1 thymocytes into the B-cell lineage, but only the Delta1-expressing stromal cells promote the proliferation and m ...[more]