Ontology highlight
ABSTRACT:
SUBMITTER: Jagasia R
PROVIDER: S-EPMC2776747 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Jagasia Ravi R Steib Kathrin K Englberger Elisabeth E Herold Sabine S Faus-Kessler Theresa T Saxe Michael M Gage Fred H FH Song Hongjun H Lie D Chichung DC
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090601 25
Survival and integration of new neurons in the hippocampal circuit are rate-limiting steps in adult hippocampal neurogenesis. Neuronal network activity is a major regulator of these processes, yet little is known about the respective downstream signaling pathways. Here, we investigate the role of cAMP response element-binding protein (CREB) signaling in adult hippocampal neurogenesis. CREB is activated in new granule neurons during a distinct developmental period. Loss of CREB function in a cell ...[more]