Recombinant squalene synthase. synthesis of cyclopentyl non-head-to-tail triterpenes.
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ABSTRACT:
SUBMITTER: Pan JJ
PROVIDER: S-EPMC2777528 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
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Recombinant squalene synthase. synthesis of cyclopentyl non-head-to-tail triterpenes.
Pan Jian-Jung JJ Bugni Tim S TS Poulter C Dale CD
The Journal of organic chemistry 20091001 19
Incubation of farnesyl diphosphate with recombinant yeast squalene synthase in the absence of NADPH gives a mixture of triterpene hydrocarbons and alcohols, including botryococcene-like compounds with 1'-3 linkages between the farnesyl units. One of these molecules has an unusual cyclopentane structure similar to those recently reported in plant extracts and lakebed sediments. ...[more]
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