Ontology highlight
ABSTRACT:
SUBMITTER: Lee H
PROVIDER: S-EPMC2777654 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Lee Heehyoung H Herrmann Andreas A Deng Jie-Hui JH Kujawski Maciej M Niu Guilian G Li Zhiwei Z Forman Steve S Jove Richard R Pardoll Drew M DM Yu Hua H
Cancer cell 20090401 4
NF-kappaB (RelA) is constitutively active in many cancers, where it upregulates antiapoptotic and other oncogenic genes. While proinflammatory stimulus-induced NF-kappaB activation involves IKK-dependent nuclear translocation, mechanisms for maintaining constitutive NF-kappaB activity in tumors have not been elucidated. We show here that maintenance of NF-kappaB activity in tumors requires Stat3, which is also frequently constitutively activated in cancer. Stat3 prolongs NF-kappaB nuclear retent ...[more]