NF-kappaB and STAT3 signaling in glioma: targets for future therapies.
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ABSTRACT:
SUBMITTER: Atkinson GP
PROVIDER: S-EPMC3886813 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
NF-kappaB and STAT3 signaling in glioma: targets for future therapies.
Atkinson George P GP Nozell Susan E SE Benveniste Etty Tika N ET
Expert review of neurotherapeutics 20100401 4
Glioblastoma remains the most clinically challenging tumor of the CNS, as evidenced by the dismal change in overall survival over the past 50 years. However, recent advances in high-throughput screening techniques have given rise to a wealth of new information regarding the aberrant signaling pathways that drive the tumor phenotype. Two of these so-called 'oncopathways' are NF-kappaB and JAK/STAT. This review will describe the basic mechanisms of these pathways, explore the relevance of NF-kappa ...[more]
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