Ontology highlight
ABSTRACT:
SUBMITTER: Deriy LV
PROVIDER: S-EPMC2778193 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Deriy Ludmila V LV Gomez Erwin A EA Jacobson David A DA Wang XueQing X Hopson Jessika A JA Liu Xiang Y XY Zhang Guangping G Bindokas Vytautas P VP Philipson Louis H LH Nelson Deborah J DJ
Cell metabolism 20091001 4
Insulin secretion from pancreatic beta cells is dependent on maturation and acidification of the secretory granule, processes necessary for prohormone convertase cleavage of proinsulin. Previous studies in isolated beta cells revealed that acidification may be dependent on the granule membrane chloride channel ClC-3, in a step permissive for a regulated secretory response. In this study, immuno-EM of beta cells revealed colocalization of ClC-3 and insulin on secretory granules. Clcn3(-/-) mice a ...[more]