The ClC-0 chloride channel is a 'broken' Cl-/H+ antiporter.
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ABSTRACT:
SUBMITTER: Lisal J
PROVIDER: S-EPMC2559860 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Publications
The ClC-0 chloride channel is a 'broken' Cl-/H+ antiporter.
Nature structural & molecular biology 20080720 8
Ion channels have historically been viewed as distinct from secondary active transporters. However, the recent discovery that the CLC 'chloride channel' family is made up of both channels and active transporters has led to the hypothesis that the ion-transport mechanisms of these two types of membrane proteins may be similar. Here we use single-channel analysis to demonstrate that ClC-0 channel gating (opening and closing) involves the transmembrane movement of protons. This result indicates tha ...[more]
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