Ontology highlight
ABSTRACT:
SUBMITTER: DeNardo DG
PROVIDER: S-EPMC2778576 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
DeNardo David G DG Barreto Jairo B JB Andreu Pauline P Vasquez Lesley L Tawfik David D Kolhatkar Nikita N Coussens Lisa M LM
Cancer cell 20090801 2
During breast cancer development, increased presence of leukocytes in neoplastic stroma parallels disease progression; however, the functional significance of leukocytes in regulating protumor versus antitumor immunity in the breast remains poorly understood. Utilizing the MMTV-PyMT model of mammary carcinogenesis, we demonstrate that IL-4-expressing CD4(+) T lymphocytes indirectly promote invasion and subsequent metastasis of mammary adenocarcinomas by directly regulating the phenotype and effe ...[more]