Ontology highlight
ABSTRACT:
SUBMITTER: Niault T
PROVIDER: S-EPMC2779248 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
The Journal of cell biology 20091101 3
The activity of Raf-1 and Rok-alpha kinases is regulated by intramolecular binding of the regulatory region to the kinase domain. Autoinhibition is relieved upon binding to the small guanosine triphosphatases Ras and Rho. Downstream of Ras, Raf-1 promotes migration and tumorigenesis by antagonizing Rok-alpha, but the underlying mechanism is unknown. In this study, we show that Rok-alpha inhibition by Raf-1 relies on an intermolecular interaction between the Rok-alpha kinase domain and the cystei ...[more]