Ontology highlight
ABSTRACT:
SUBMITTER: Visnapuu ML
PROVIDER: S-EPMC2779460 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Visnapuu Mari-Liis ML Greene Eric C EC
Nature structural & molecular biology 20090906 10
Here we use single-molecule imaging to determine coarse-grained intrinsic energy landscapes for nucleosome deposition on model DNA substrates. Our results reveal distributions that are correlated with recent in silico predictions, reinforcing the hypothesis that DNA contains some intrinsic positioning information. We also show that cis-regulatory sequences in human DNA coincide with peaks in the intrinsic landscape, whereas valleys correspond to nonregulatory regions, and we present evidence arg ...[more]