Ontology highlight
ABSTRACT:
SUBMITTER: Renthal W
PROVIDER: S-EPMC2779727 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Renthal William W Kumar Arvind A Xiao Guanghua G Wilkinson Matthew M Covington Herbert E HE Maze Ian I Sikder Devanjan D Robison Alfred J AJ LaPlant Quincey Q Dietz David M DM Russo Scott J SJ Vialou Vincent V Chakravarty Sumana S Kodadek Thomas J TJ Stack Ashley A Kabbaj Mohamed M Nestler Eric J EJ
Neuron 20090501 3
Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly understood. Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our findings re ...[more]