Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Lluch S
PROVIDER: S-EPMC3113561 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Pérez-Lluch Sílvia S Blanco Enrique E Carbonell Albert A Raha Debasish D Snyder Michael M Serras Florenci F Corominas Montserrat M
Nucleic acids research 20110209 11
An important mechanism for gene regulation involves chromatin changes via histone modification. One such modification is histone H3 lysine 4 trimethylation (H3K4me3), which requires histone methyltranferase complexes (HMT) containing the trithorax-group (trxG) protein ASH2. Mutations in ash2 cause a variety of pattern formation defects in the Drosophila wing. We have identified genome-wide binding of ASH2 in wing imaginal discs using chromatin immunoprecipitation combined with sequencing (ChIP-S ...[more]