Ontology highlight
ABSTRACT: Aims
Assess the efficacy and safety of saxagliptin added to a submaximal sulphonylurea dose vs. uptitration of sulphonylurea monotherapy in patients with type 2 diabetes and inadequate glycaemic control with sulphonylurea monotherapy.Methods and patients
A total of 768 patients (18-77 years; HbA(1c) screening >or= 7.5 to Conclusion
Saxagliptin added to submaximal glyburide therapy led to statistically significant improvements vs. uptitration of glyburide alone across key glycaemic parameters and was generally well tolerated.
SUBMITTER: Chacra AR
PROVIDER: S-EPMC2779994 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Chacra A R AR Tan G H GH Apanovitch A A Ravichandran S S List J J Chen R R
International journal of clinical practice 20090715 9
<h4>Aims</h4>Assess the efficacy and safety of saxagliptin added to a submaximal sulphonylurea dose vs. uptitration of sulphonylurea monotherapy in patients with type 2 diabetes and inadequate glycaemic control with sulphonylurea monotherapy.<h4>Methods and patients</h4>A total of 768 patients (18-77 years; HbA(1c) screening >or= 7.5 to <or= 10.0%) were randomised and treated with saxagliptin 2.5 or 5 mg in combination with glyburide 7.5 mg vs. glyburide 10 mg for 24 weeks. Blinded uptitration g ...[more]