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A neural circuit mechanism integrating motivational state with memory expression in Drosophila.

ABSTRACT: Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory.

SUBMITTER: Krashes MJ

PROVIDER: S-EPMC2780032 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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A neural circuit mechanism integrating motivational state with memory expression in Drosophila.

Krashes Michael J MJ DasGupta Shamik S DasGupta Shamik S Vreede Andrew A White Benjamin B Armstrong J Douglas JD Waddell Scott S

Cell 20091001 2

Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF rec ...[more]

PMID: 19837040

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