Ontology highlight
ABSTRACT:
SUBMITTER: Wagner MJ
PROVIDER: S-EPMC8844704 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Wagner Mark J MJ Savall Joan J Hernandez Oscar O Mel Gabriel G Inan Hakan H Rumyantsev Oleg O Lecoq Jérôme J Kim Tony Hyun TH Li Jin Zhong JZ Ramakrishnan Charu C Deisseroth Karl K Luo Liqun L Ganguli Surya S Schnitzer Mark J MJ
Cell 20210701 14
In motor neuroscience, state changes are hypothesized to time-lock neural assemblies coordinating complex movements, but evidence for this remains slender. We tested whether a discrete change from more autonomous to coherent spiking underlies skilled movement by imaging cerebellar Purkinje neuron complex spikes in mice making targeted forelimb-reaches. As mice learned the task, millimeter-scale spatiotemporally coherent spiking emerged ipsilateral to the reaching forelimb, and consistent neural ...[more]