Ontology highlight
ABSTRACT:
SUBMITTER: del Pilar Alatorre-Carranza M
PROVIDER: S-EPMC2780448 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
del Pilar Alatorre-Carranza María M Miranda-Díaz Alejandra A Yañez-Sánchez Irinea I Pizano-Martínez Oscar O Hermosillo-Sandoval José M JM Vázquez-Del Mercado Mónica M Hernández-Hoyos Sebastián S Martínez-Abundis Ricardo R Fafutis-Morris Mary M Segura-Ortega Jorge J Delgado-Rizo Vidal V
BMC gastroenterology 20091031
<h4>Background</h4>Liver fibrosis is the result of continuous liver injury stemming from different etiological factors. Bile duct injury induces an altered expression of TGF-beta, which has an important role in liver fibrosis because this cytokine induces the expression of target genes such as collagens, PAI-1, TIMPs, and others that lead to extracellular matrix deposition. Smad7 is the principal inhibitor that regulates the target gene transcription of the TGF-beta signaling. The aim of the stu ...[more]