Dataset Information

Genetics of cardiovascular disease.

ABSTRACT: Linkage studies and genome-wide linkage analyses, which use polymorphic DNA markers throughout the genome, provide a useful method for identifying genes related to cardiovascular disease (CVD). Many genome-wide linkage studies have contributed to identify quantitative genetic loci influencing variables involved in the pathogenesis of CVD.Meta-analyses of genetic studies provide the measure of association studies, so contributing to identify candidate genes which might influence the susceptibility to the disease. Really, candidate genes have been investigated, in relation to lipid metabolism (APOE), fibrinolytic proteins (PAI-1), renin-angiotensyn system (ACE) and homocysteine metabolism (MTHFR). Recently, genome-wide panels of common single nucleotide polymorphisms (SNPs), based on the use of SNPs spread throughout the genome, are also becoming available. This approach contributes to finely investigate the gene-gene and gene-environment interactions in CVD, and to look for the involvement of genetic polymorphisms in drug response.

SUBMITTER: Abbate R

PROVIDER: S-EPMC2781194 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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Genetics of cardiovascular disease.

Abbate Rosanna R Sticchi Elena E Fatini Cinzia C

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20080101 1

Linkage studies and genome-wide linkage analyses, which use polymorphic DNA markers throughout the genome, provide a useful method for identifying genes related to cardiovascular disease (CVD). Many genome-wide linkage studies have contributed to identify quantitative genetic loci influencing variables involved in the pathogenesis of CVD.Meta-analyses of genetic studies provide the measure of association studies, so contributing to identify candidate genes which might influence the susceptibilit ...[more]

PMID: 22460848

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Project description:Coronary artery disease (CAD) is a complex disease with environmental and genetic determinants. Many other cardiovascular (CV) conditions also have a genetic basis. A positive family history of CV disease in first-degree relatives is a strong independent risk factor for CAD as well as several other cardiac disorders. This genetic susceptibility to CV diseases will be understood more clearly when combined with genomics, proteomics and genotyping.The Department of Cardiology at Gold Coast Hospital (Queensland, Australia) with the Faculty of Health, Science and Medicine at Bond University (Queensland, Australia) established the Gold Coast Cardiovascular DNA bank in 2006. The dataset on each individual volunteer includes coronary angiograms, clinical information (including a coronary risk factor profile), biochemical (including cardiac biomarkers) and hematological parameters, and electrocardiograms and echocardiograms. The establishment of the DNA biobank was associated with several key challenges, both technical and logistic.Given the comprehensive nature of the information gathered, the present study has the added potential of identifying genes associated with nonischemic cardiomyopathies, valvular heart disease, congenital heart diseases and other cardiomyopathies. Pooling data from results obtained here with multiple existing DNA biobanks and registries will help in finding answers to the genetic conundrum in CV diseases. The present DNA biobank will serve as a resource well into the future as the technology and science of medical genetics evolve.The most frequent pathology encountered in the biobank is CAD. The significance of the familial occurrence of CAD has been the focus of research for at least 50 years, with a positive family history of CV disease emerging as an independent predictor of risk in the development of CAD. By applying the knowledge learned from studies on CV genetics together with the data from the DNA biobank, scientists may be able to effectively prevent and treat CV diseases in the future.

Dataset Information

Genetics of cardiovascular disease.

Publications

Genetics of cardiovascular disease.

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