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Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.

ABSTRACT: Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.

SUBMITTER: Kraja AT

PROVIDER: S-EPMC3063340 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

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Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.

Kraja Aldi T AT Hunt Steven C SC Rao D C DC Dávila-Román Victor G VG Arnett Donna K DK Province Michael A MA

Current hypertension reports 20110201 1

Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in ...[more]

PMID: 21128019

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Dataset Information

Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.

Publications

Genetics of hypertension and cardiovascular disease and their interconnected pathways: lessons from large studies.

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