Ontology highlight
ABSTRACT:
SUBMITTER: Monette A
PROVIDER: S-EPMC2781532 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Monette Anne A Ajamian Lara L López-Lastra Marcelo M Mouland Andrew J AJ
The Journal of biological chemistry 20090908 45
Human immunodeficiency virus type 1 (HIV-1) co-opts host proteins and cellular machineries to its advantage at every step of the replication cycle. Here we show that HIV-1 enhances heterogeneous nuclear ribonucleoprotein (hnRNP) A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm. The latter was dependent on the nuclear export of the unspliced viral genomic RNA (vRNA) and to alterations in the abundance and localization of the FG-repeat nuclear pore glycoprotein p62. hnRNP ...[more]