Ontology highlight
ABSTRACT:
SUBMITTER: Smith AN
PROVIDER: S-EPMC2782108 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Smith Annabel N AN Francis Richard W RW Sorrell Sara L SL Karet Fiona E FE
Journal of bioenergetics and biomembranes 20080828 4
The multi-subunit vacuolar-type H(+)-ATPase consists of a V(1) domain (A-H subunits) catalyzing ATP hydrolysis and a V(0) domain (a, c, c', c", d, e) responsible for H(+) translocation. The mammalian V(0) d subunit is one of the least-well characterized, and its function and position within the pump are still unclear. It has two different forms encoded by separate genes, d1 being ubiquitous while d2 is predominantly expressed at the cell surface in kidney and osteoclast. To determine whether it ...[more]