CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
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ABSTRACT:
SUBMITTER: DeBruyne JP
PROVIDER: S-EPMC2782643 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Publications
CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
DeBruyne Jason P JP Weaver David R DR Reppert Steven M SM
Nature neuroscience 20070408 5
Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity. ...[more]
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