Ontology highlight
ABSTRACT:
SUBMITTER: Masson D
PROVIDER: S-EPMC2783626 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Masson David D Koseki Masahiro M Ishibashi Minako M Larson Christopher J CJ Miller Stephen G SG King Bernard D BD Tall Alan R AR
Arteriosclerosis, thrombosis, and vascular biology 20091008 12
<h4>Objective</h4>Increasing HDL levels is a potential strategy for the treatment of atherosclerosis.<h4>Methods and results</h4>ITX5061, a molecule initially characterized as a p38 MAPK inhibitor, increased HDL-C levels by 20% in a human population of hypertriglyceridemic subjects with low HDL levels. ITX5061 also moderately increased apoA-I but did not affect VLDL/LDL cholesterol or plasma triglyceride concentrations. ITX5061 increased HDL-C in WT and human apoA-I transgenic mice, and kinetic ...[more]