Ontology highlight
ABSTRACT:
SUBMITTER: Radisky DC
PROVIDER: S-EPMC2784913 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Radisky Derek C DC Levy Dinah D DD Littlepage Laurie E LE Liu Hong H Nelson Celeste M CM Fata Jimmie E JE Leake Devin D Godden Elizabeth L EL Albertson Donna G DG Nieto M Angela MA Werb Zena Z Bissell Mina J MJ
Nature 20050701 7047
The tumour microenvironment can be a potent carcinogen, not only by facilitating cancer progression and activating dormant cancer cells, but also by stimulating tumour formation. We have previously investigated stromelysin-1/matrix metalloproteinase-3 (MMP-3), a stromal enzyme upregulated in many breast tumours, and found that MMP-3 can cause epithelial-mesenchymal transition (EMT) and malignant transformation in cultured cells, and genomically unstable mammary carcinomas in transgenic mice. Her ...[more]