Ontology highlight
ABSTRACT:
SUBMITTER: Sharma V
PROVIDER: S-EPMC2785149 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Sharma Vikram V Heriot William W Trisler Kirk K Smider Vaughn V
The Journal of biological chemistry 20091002 48
Antibodies with nucleophilic or catalytic properties often have these characteristics encoded in their germ line genes. Because hydrolytic activity has been reported to be associated with light chain V regions, we have begun an analysis of germ line light chain proteins that could be the basis for affinity maturation into hydrolytic or other reactive antibodies. We produced the germ line A18b light chain and characterized its hydrolytic, nucleophilic, and tertiary structural activities. This lig ...[more]