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CRF system recruitment mediates dark side of compulsive eating.


ABSTRACT: Dieting to control body weight involves cycles of deprivation from palatable food that can promote compulsive eating. The present study shows that rats withdrawn from intermittent access to palatable food exhibit overeating of palatable food upon renewed access and an affective withdrawal-like state characterized by corticotropin-releasing factor-1 (CRF(1)) receptor antagonist-reversible behaviors, including hypophagia, motivational deficits to obtain less palatable food, and anxiogenic-like behavior. Withdrawal was accompanied by increased CRF expression and CRF(1) electrophysiological responsiveness in the central nucleus of the amygdala. We propose that recruitment of anti-reward extrahypothalamic CRF-CRF(1) systems during withdrawal from palatable food, analogous to abstinence from abused drugs, may promote compulsive selection of palatable food, undereating of healthier alternatives, and a negative emotional state when intake of palatable food is prevented.

SUBMITTER: Cottone P 

PROVIDER: S-EPMC2785284 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature

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CRF system recruitment mediates dark side of compulsive eating.

Cottone Pietro P   Sabino Valentina V   Roberto Marisa M   Bajo Michal M   Pockros Lara L   Frihauf Jennifer B JB   Fekete Eva M EM   Steardo Luca L   Rice Kenner C KC   Grigoriadis Dimitri E DE   Conti Bruno B   Koob George F GF   Zorrilla Eric P EP  

Proceedings of the National Academy of Sciences of the United States of America 20091109 47


Dieting to control body weight involves cycles of deprivation from palatable food that can promote compulsive eating. The present study shows that rats withdrawn from intermittent access to palatable food exhibit overeating of palatable food upon renewed access and an affective withdrawal-like state characterized by corticotropin-releasing factor-1 (CRF(1)) receptor antagonist-reversible behaviors, including hypophagia, motivational deficits to obtain less palatable food, and anxiogenic-like beh  ...[more]

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