Ontology highlight
ABSTRACT:
SUBMITTER: Cottone P
PROVIDER: S-EPMC2785284 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Cottone Pietro P Sabino Valentina V Roberto Marisa M Bajo Michal M Pockros Lara L Frihauf Jennifer B JB Fekete Eva M EM Steardo Luca L Rice Kenner C KC Grigoriadis Dimitri E DE Conti Bruno B Koob George F GF Zorrilla Eric P EP
Proceedings of the National Academy of Sciences of the United States of America 20091109 47
Dieting to control body weight involves cycles of deprivation from palatable food that can promote compulsive eating. The present study shows that rats withdrawn from intermittent access to palatable food exhibit overeating of palatable food upon renewed access and an affective withdrawal-like state characterized by corticotropin-releasing factor-1 (CRF(1)) receptor antagonist-reversible behaviors, including hypophagia, motivational deficits to obtain less palatable food, and anxiogenic-like beh ...[more]