Ontology highlight
ABSTRACT:
SUBMITTER: Prochazkova K
PROVIDER: S-EPMC2785344 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Prochazkova Katerina K Shuvalova Ludmilla A LA Minasov George G Voburka Zdenek Z Anderson Wayne F WF Satchell Karla J F KJ
The Journal of biological chemistry 20090720 39
The multifunctional autoprocessing repeats-in-toxin (MARTX) toxin of Vibrio cholerae causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases. The effector domains responsible for these activities are here shown to be independent proteins released from the large toxin by autoproteolysis catalyzed by an embedded cysteine protease domain (CPD). The CPD is activated upon binding inositol hexakisphosphate (InsP(6)). In this study, we demonstrate ...[more]