Ontology highlight
ABSTRACT:
SUBMITTER: Kudryashov DS
PROVIDER: S-EPMC2587553 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Kudryashov Dmitri S DS Durer Zeynep A Oztug ZA Ytterberg A Jimmy AJ Sawaya Michael R MR Pashkov Inna I Prochazkova Katerina K Yeates Todd O TO Loo Rachel R Ogorzalek RR Loo Joseph A JA Satchell Karla J Fullner KJ Reisler Emil E
Proceedings of the National Academy of Sciences of the United States of America 20081117 47
The Gram-negative bacterium Vibrio cholerae is the causative agent of a severe diarrheal disease that afflicts three to five million persons annually, causing up to 200,000 deaths. Nearly all V. cholerae strains produce a large multifunctional-autoprocessing RTX toxin (MARTX(Vc)), which contributes significantly to the pathogenesis of cholera in model systems. The actin cross-linking domain (ACD) of MARTX(Vc) directly catalyzes a covalent cross-linking of monomeric G-actin into oligomeric chains ...[more]