Ontology highlight
ABSTRACT:
SUBMITTER: Hao M
PROVIDER: S-EPMC2785582 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Hao Mingming M Bogan Jonathan S JS
The Journal of biological chemistry 20090903 43
Membrane cholesterol modulates the ability of glucose to stimulate insulin secretion from pancreatic beta-cells. The molecular mechanism by which this occurs is not understood. Here, we show that in cultured beta-cells, cholesterol acts through phosphatidylinositol 4,5-bisphosphate (PIP(2)) to regulate actin dynamics, plasma membrane potential, and glucose-stimulated insulin secretion. Cholesterol-overloaded beta-cells exhibited decreased PIP(2) hydrolysis, with diminished glucose-induced actin ...[more]