Ontology highlight
ABSTRACT:
SUBMITTER: Antonescu CN
PROVIDER: S-EPMC3135483 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Antonescu Costin N CN Aguet François F Danuser Gaudenz G Schmid Sandra L SL
Molecular biology of the cell 20110525 14
Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin-coated pits (CCPs). Nearly half of nascent CCPs abort, whereas others are stabilized by unknown mechanisms and undergo further maturation before pinching off to form clathrin-coated vesicles (CCVs). Phosphatidylinositol-(4,5)-bisphosphate (PIP(2)), the main lipid binding partner of endocytic proteins, is required for CCP assembl ...[more]