Ontology highlight
ABSTRACT:
SUBMITTER: Qiao L
PROVIDER: S-EPMC2785710 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20090909 21
A structure-activity relationship study for a 2-chloroanilide derivative of pyrazolo[1,5-a]pyridine revealed that increased EphB3 kinase inhibitory activity could be accomplished by retaining the 2-chloroanilide and introducing a phenyl or small electron donating substituents to the 5-position of the pyrazolo[1,5-a]pyridine. In addition, replacement of the pyrazolo[1,5-a]pyridine with imidazo[1,2-a]pyridine was well tolerated and resulted in enhanced mouse liver microsome stability. The structur ...[more]