Ontology highlight
ABSTRACT:
SUBMITTER: Laha JK
PROVIDER: S-EPMC3062192 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Laha Joydev K JK Zhang Xuemei X Qiao Lixin L Liu Min M Chatterjee Snigdha S Robinson Shaughnessy S Kosik Kenneth S KS Cuny Gregory D GD
Bioorganic & medicinal chemistry letters 20110203 7
Cdk5/p25 has emerged as a principle therapeutic target for numerous acute and chronic neurodegenerative diseases, including Alzheimer's disease. A structure-activity relationship study of 2,4-diaminothiazole inhibitors revealed that increased Cdk5/p25 inhibitory activity could be accomplished by incorporating pyridines on the 2-amino group and addition of substituents to the 2- or 3-position of the phenyl ketone moiety. Interpretation of the SAR results for many of the analogs was aided through ...[more]