Ontology highlight
ABSTRACT:
SUBMITTER: Harrison DE
PROVIDER: S-EPMC2786175 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Harrison David E DE Strong Randy R Sharp Zelton Dave ZD Nelson James F JF Astle Clinton M CM Flurkey Kevin K Nadon Nancy L NL Wilkinson J Erby JE Frenkel Krystyna K Carter Christy S CS Pahor Marco M Javors Martin A MA Fernandez Elizabeth E Miller Richard A RA
Nature 20090708 7253
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR signalling can extend lifespan in a mammalian species was unknown. Here we report that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age. On the basis of age at 90% mortality, rapamycin led to an increase ...[more]