Ontology highlight
ABSTRACT:
SUBMITTER: Livi CB
PROVIDER: S-EPMC3616197 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Livi Carolina B CB Hardman Rulon L RL Christy Barbara A BA Dodds Sherry G SG Jones Diane D Williams Charnae C Strong Randy R Bokov Alex A Javors Martin A MA Ikeno Yuji Y Hubbard Gene G Hasty Paul P Sharp Zelton Dave ZD
Aging 20130201 2
Chronic treatment of mice with an enterically released formulation of rapamycin (eRapa) extends median and maximum life span, partly by attenuating cancer. The mechanistic basis of this response is not known. To gain a better understanding of thesein vivo effects, we used a defined preclinical model of neuroendocrine cancer, Rb1+/- mice. Previous results showed that diet restriction (DR) had minimal or no effect on the lifespan of Rb1+/- mice, suggesting that the beneficial response to DR is dep ...[more]