Ontology highlight
ABSTRACT:
SUBMITTER: Vidovic D
PROVIDER: S-EPMC2786264 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Vidović Dusica D Schürer Stephan C SC
Journal of medicinal chemistry 20091101 21
Tyrosine phosphorylation, controlled by the coordinated action of protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs), is a fundamental regulatory mechanism of numerous physiological processes. PTPs are implicated in a number of human diseases, and their potential as prospective drug targets is increasingly being recognized. Despite their biological importance, until now no comprehensive overview has been reported describing how all members of the human PTP family are relate ...[more]