Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B.
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ABSTRACT:
SUBMITTER: Wiese J
PROVIDER: S-EPMC5484141 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B.
Wiese Jutta J Aldemir Hülya H Schmaljohann Rolf R Gulder Tobias A M TAM Imhoff Johannes F JF
Marine drugs 20170621 6
In the frame of studies on secondary metabolites produced by fungi from deep-sea environments we have investigated inhibitors of enzymes playing key roles in signaling cascades of biochemical pathways relevant for the treatment of diseases. Here we report on a new inhibitor of the human protein tyrosine phosphatase 1B (PTP1B), a target in the signaling pathway of insulin. A new asperentin analog is produced by an <i>Aspergillus</i><i>sydowii</i> strain isolated from the sediment of the deep Medi ...[more]
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