ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
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ABSTRACT:
SUBMITTER: Inaoka T
PROVIDER: S-EPMC2786573 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
ScoC regulates bacilysin production at the transcription level in Bacillus subtilis.
Inaoka Takashi T Wang Guojun G Ochi Kozo K
Journal of bacteriology 20091002 23
Bacillus subtilis mutants with high expression of the bacilysin operon ywfBCDEFG were isolated. Comparative genome sequencing analysis revealed that all of these mutants have a mutation in the scoC gene. The disruption of scoC by genetic engineering also resulted in increased expression of ywfBCDEFG. Primer extension and gel mobility shift analyses showed that the ScoC protein binds directly to the promoter region of ywfBCDEFG. Our results indicate that the transition state regulator ScoC, toget ...[more]
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