Ontology highlight
ABSTRACT:
SUBMITTER: Chen YE
PROVIDER: S-EPMC2786585 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Chen Y Erin YE Tsokos Christos G CG Biondi Emanuele G EG Perchuk Barrett S BS Laub Michael T MT
Journal of bacteriology 20090925 24
In Caulobacter crescentus, progression through the cell cycle is governed by the periodic activation and inactivation of the master regulator CtrA. Two phosphorelays, each initiating with the histidine kinase CckA, promote CtrA activation by driving its phosphorylation and by inactivating its proteolysis. Here, we examined whether the CckA phosphorelays also influence the downregulation of CtrA. We demonstrate that CckA is bifunctional, capable of acting as either a kinase or phosphatase to driv ...[more]