Ontology highlight
ABSTRACT:
SUBMITTER: Mutch CA
PROVIDER: S-EPMC2786782 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Mutch Christopher A CA Funatsu Nobuo N Monuki Edwin S ES Chenn Anjen A
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091001 43
The mechanisms underlying the timing of the laminar fate decisions during cortical neurogenesis remain poorly understood. Here we show that beta-catenin signaling in cortical neural precursors can regulate the laminar fate of their daughters. In ventricular zone neural precursors, beta-catenin signaling is higher when deep-layer neurons are being generated and lower when upper-layer neurons are being generated. Overactivation of beta-catenin in cortical precursors midway through corticogenesis i ...[more]