Ontology highlight
ABSTRACT:
SUBMITTER: Cierpicki T
PROVIDER: S-EPMC2786971 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Cierpicki Tomasz T Bielnicki Jakub J Zheng Meiying M Gruszczyk Jakub J Kasterka Marta M Petoukhov Maxim M Zhang Aming A Fernandez Erik J EJ Svergun Dmitri I DI Derewenda Urszula U Bushweller John H JH Derewenda Zygmunt S ZS
Protein science : a publication of the Protein Society 20091001 10
The DH-PH domain tandems of Dbl-homology guanine nucleotide exchange factors catalyze the exchange of GTP for GDP in Rho-family GTPases, and thus initiate a wide variety of cellular signaling cascades. Although several crystal structures of complexes of DH-PH tandems with cognate, nucleotide free Rho GTPases are known, they provide limited information about the dynamics of the complex and it is not clear how accurately they represent the structures in solution. We used a complementary combinatio ...[more]