Ontology highlight
ABSTRACT:
SUBMITTER: Abdul Azeez KR
PROVIDER: S-EPMC4232260 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Abdul Azeez Kamal R KR Knapp Stefan S Fernandes João M P JM Klussmann Enno E Elkins Jonathan M JM
The Biochemical journal 20141201 2
The RhoGEF (Rho GTPase guanine-nucleotide-exchange factor) domain of AKAP-Lbc (A-kinase-anchoring protein-Lbc, also known as AKAP13) catalyses nucleotide exchange on RhoA and is involved in the development of cardiac hypertrophy. The RhoGEF activity of AKAP-Lbc has also been implicated in cancer. We have determined the X-ray crystal structure of the complex between RhoA-GDP and the AKAP-Lbc RhoGEF [DH (Dbl-homologous)-PH (pleckstrin homology)] domain to 2.1 Å (1 Å = 0.1 nm) resolution. The struc ...[more]